49ers vs Seahawks Prediction, Picks & Odds | 07 Sep 2025

NFL Betting Preview: Niners vs Seahawks

The San Francisco 49ers meet the Seattle Seahawks in this NFL Week 1 matchup at Lumen Field, with kickoff scheduled for 04:05 on Monday 8 September. Our betting preview features expert predictions, picks, updated betting odds, head-to-head stats and the latest team news, including injuries.

Why Seahawks Can Claim the Win

Our betting prediction is that there will be home-field advantage when the Seahawks face the Niners. You can currently get 2.00 about this happening which look like great odds.

Backing Seahawks? Don’t miss the chance to use the latest Stake promo code and be sure to check out our comprehensive review too.

Seahawks Won Last H2H Encounter

San Francisco 49ers suffered a defeat in their previous game. A 47-24 scoreline occurred on the road at State Farm Stadium against Arizona Cardinals. The Niners recorded 436 yards, with 298 through the air and 138 on the ground. They picked up 26 first downs and found the end zone 3 times.

Seattle Seahawks won their last game 30-25. This was a road victory at SoFi Stadium against Los Angeles Rams. The Seahawks moved the ball for 336 yards, breaking down to 210 passing and 126 rushing yards. The offense moved the chains 18 times and struck for 4 touchdowns.

Head-to-Head Statistics

The Seahawks triumphed 20-17 when they last played the Niners. This head-to-head was played at Levi's Stadium. The Niners have won six of the past 10 games that these teams have played.

Quarterbacks

Brock Purdy

Sam Darnold

49ers vs Seahawks Prediction & Picks

Discover our expert 49ers vs Seahawks betting tips, featuring a key match prediction, correct score suggestion, top player prop picks and bet builder advice. Scroll down for full analysis.

Game Prediction

There are lots of reasons to support the pick that the Seahawks will win this NFL matchup. Therefore, we’re heading to the Moneyline where you can get 2.00.

Getting the lowdown on injuries and analyzing the form guide are key steps before making NFL picks. We also put strong emphasis on stats, where a data-led approach often leads to smarter predictions.

Key 49ers vs Seahawks stats:

• Seahawks have won 6 of their last 10 games.
• Seahawks have won 12 of their last 20 games.
• Seahawks have won 2 consecutive games.
• 49ers have lost their last 4 games.
• 49ers have lost 7 of their last 10 games.
• 49ers have lost 12 of their last 20 games.

Seahawks Moneyline Probability

When you look at the latest betting odds, our pick has a 50% chance of winning. Our cappers think there’s a stronger chance of success and calculate the probability to be 55-60%. It’s why we think it’s worth placing this bet.

Fancy the Seahawks to triumph but want more juice in the odds? Why not take a look at the spread and consider them to cover one of the available lines.

Before your next wager, read our guide featuring today’s top betting offers, free bet deals, and sign-up bonuses.

Best Bet

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Player Prop Picks

Correct Score Prediction

49ers 20 - 27 Seahawks

We’re going for the Seahawks to win by a 27-20 scoreline, something which is available at huge odds. This speculative wager can provide a big return for a small stake.

49ers vs Seahawks Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Books Predicting a Close Encounter

The betting odds about Seattle Seahawks winning is 2.12, with San Francisco 49ers priced up at 1.76 to achieve victory. In the eyes of the leading sportsbooks, the home team are regarded as 47% likely to claim a victory.

1.5 is the spread and 43.5 is the total points line. NFL fans regularly enjoy the opportunity to bet on the Totals. Those expecting a low total can back Under 43.5 at 1.85.

The best NFL sportsbooks offer a wide range of team props and game lines for every matchup. Make sure you look through all the available options before deciding which bet to place.

Christian McCaffrey Favorite to Be First TD Scorer

The First TD Scorer favorite is Christian McCaffrey at 5.30. Similar odds can be found if you’re interested in this player to register the last touchdown.

Touchdown

Receiving Yards

Rushing Yards

Passing Yards

Micro Betting

It’s possible to use stats to your advantage when it comes to NFL micro betting, especially if you’re predicting outcomes such as the Next Drive Result. Check out the live team, score and player props and see if you can find an angle.

Niners Hold Edge in Recent Head-to-Head Matchups at Lumen Field

The Seahawks have gone 3-7 across their last 10 home games, putting up 20.00 points on average and giving up 23.80.

The Niners have dropped four road games in a row. They have a 3-7 record in their last 10 games away from home, posting 21.00 points per contest while yielding 27.80.

The previous meeting at Lumen Field saw the Niners defeat the Seahawks 36-24. Looking back at the last 6 head-to-head meetings at Lumen Field, the Niners have posted four victories, while the Seahawks have logged two.

Last 10 Games		W-L	P	PF	PA	O43.5	U43.5
Seahawks Home Stats		3-7	43.80	20.00	23.80	6	4
49ers Away Stats		3-7	48.80	21.00	27.80	7	3

• W-L = Wins-Losses
• P = Avg. Points
• PF = Avg. Points For
• PA = Avg. Points Against
• O43.5 = Games Over 43.5 Points
• U43.5 = Games Under 43.5 Points

Last 5 & H2H

Latest regular season and playoff games stats.

San Francisco 49ers Stats

Seattle Seahawks Stats

Moneyline

• 3 wins and 7 defeats in the last 10 games
• 3 wins and 7 defeats in the last 10 games on the road

Moneyline

• 6 wins and 4 defeats in the last 10 games
• 3 wins and 7 defeats in the last 10 home games

Point Spread

• -1.5 Betting Line: Have covered the spread in 3 of the last 10 games
• -1.5 Betting Line on the Road: Have covered the spread in 3 of the last 10 games on the road

Point Spread

• +1.5 Betting Line: Have covered the spread in 6 of the last 10 games
• +1.5 Betting Line at Home: Have covered the spread in 3 of the last 10 home games

Total Points

• Game Totals: An average of 48.70 pts in the previous 10 games
• Game Totals on the Road: An average of 48.80 pts in the previous 10 games on the road
• Over 43.5: Covered in 7 of the previous 10 games
• Over 43.5 on the Road: Covered in 7 of the previous 10 games on the road
• Team Totals: Have scored an average of 20.90 pts and allowed 27.80 pts in the last 10 games
• Team Totals on the Road: Have scored an average of 21.00 pts and allowed 27.80 pts in the last 10 games on the road

Total Points

• Game Totals: An average of 39.90 pts in the previous 10 games
• Game Totals at Home: An average of 43.80 pts in the previous 10 home games
• Over 43.5: Covered in 5 of the previous 10 games
• Over 43.5 at Home: Covered in 6 of the previous 10 home games
• Team Totals: Have scored an average of 19.50 pts and allowed 20.40 pts in the last 10 games
• Team Totals at Home: Have scored an average of 20.00 pts and allowed 23.80 pts in the last 10 home games

Game Stats

Last 10 Games

• Total Yards: Gained 356.70 Yds. Allowed 317.10 Yds
• Rushing Yards: Gained 111.40 Yds. Allowed 132.90 Yds
• Passing Yards: Gained 245.30 Yds. Allowed 184.20 Yds
• Total Touchdowns: Scored 2.40 TD. Allowed 3.20 TD
• Rushing Touchdowns: Scored 1.00 TD. Allowed 1.50 TD
• Passing Touchdowns: Scored 1.40 TD. Allowed 1.70 TD
• Total 1st Downs: Picked up 19.80. Allowed 19.60
• Total Turnovers: Committed 1.70. Committed by opponents 0.40
• Total Penalties: Committed 7.40. Committed by opponents 4.40
• Penalty Yards: Lost 52.40 Yds. Gained 34.40 Yds

Game Stats

Last 10 Games

• Total Yards: Gained 306.90 Yds. Allowed 324.90 Yds
• Rushing Yards: Gained 94.50 Yds. Allowed 103.00 Yds
• Passing Yards: Gained 212.40 Yds. Allowed 221.90 Yds
• Total Touchdowns: Scored 2.20 TD. Allowed 2.20 TD
• Rushing Touchdowns: Scored 0.70 TD. Allowed 0.40 TD
• Passing Touchdowns: Scored 1.40 TD. Allowed 1.60 TD
• Total 1st Downs: Picked up 17.40. Allowed 19.60
• Total Turnovers: Committed 1.40. Committed by opponents 1.20
• Total Penalties: Committed 6.80. Committed by opponents 7.00
• Penalty Yards: Lost 59.30 Yds. Gained 54.40 Yds

Last 10 Games on the Road

• Total Yards: Gained 380.00 Yds. Allowed 342.40 Yds
• Rushing Yards: Gained 125.20 Yds. Allowed 130.50 Yds
• Passing Yards: Gained 254.80 Yds. Allowed 211.90 Yds
• Total Touchdowns: Scored 2.30 TD. Allowed 3.10 TD
• Rushing Touchdowns: Scored 0.50 TD. Allowed 1.30 TD
• Passing Touchdowns: Scored 1.80 TD. Allowed 1.70 TD
• Total 1st Downs: Picked up 21.70. Allowed 20.20
• Total Turnovers: Committed 1.60. Committed by opponents 0.90
• Total Penalties: Committed 6.60. Committed by opponents 5.70
• Penalty Yards: Lost 45.00 Yds. Gained 45.90 Yds

Last 10 Home Games

• Total Yards: Gained 324.50 Yds. Allowed 358.30 Yds
• Rushing Yards: Gained 83.10 Yds. Allowed 127.10 Yds
• Passing Yards: Gained 241.40 Yds. Allowed 231.20 Yds
• Total Touchdowns: Scored 2.30 TD. Allowed 2.40 TD
• Rushing Touchdowns: Scored 0.80 TD. Allowed 0.80 TD
• Passing Touchdowns: Scored 1.30 TD. Allowed 1.40 TD
• Total 1st Downs: Picked up 18.70. Allowed 20.20
• Total Turnovers: Committed 1.90. Committed by opponents 0.80
• Total Penalties: Committed 8.00. Committed by opponents 6.60
• Penalty Yards: Lost 67.00 Yds. Gained 53.40 Yds

Team News

NFL Standings Select Season 2025/20262024/20252023/20242022/20232021/20222020/20212019/2020

Division Conference League

AFC East	W	L	T	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Bills	2	0	0	1.000	71	50	21	1-0-0	1-0-0	1-0-0	2-0-0	2-0-0	2W
Patriots	1	1	0	0.500	46	47	-1	0-1-0	1-0-0	1-0-0	1-1-0	1-1-0	1W
Jets	0	2	0	0.000	42	64	-22	0-2-0	0-0-0	0-1-0	0-2-0	0-2-0	2L
Dolphins	0	2	0	0.000	35	66	-31	0-1-0	0-1-0	0-1-0	0-2-0	0-2-0	2L

AFC North	W	L	T	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Bengals	2	0	0	1.000	48	43	5	1-0-0	1-0-0	1-0-0	2-0-0	2-0-0	2W
Ravens	1	1	0	0.500	81	58	23	1-0-0	0-1-0	1-0-0	1-1-0	1-1-0	1W
Steelers	1	1	0	0.500	51	63	-12	0-1-0	1-0-0	0-0-0	1-0-0	1-1-0	1L
Browns	0	2	0	0.000	33	58	-25	0-1-0	0-1-0	0-2-0	0-2-0	0-2-0	2L

AFC South	W	L	T	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Colts	2	0	0	1.000	62	36	26	2-0-0	0-0-0	0-0-0	2-0-0	2-0-0	2W
Jaguars	1	1	0	0.500	53	41	12	1-0-0	0-1-0	0-0-0	0-1-0	1-1-0	1L
Texans	0	2	0	0.000	28	34	-6	0-1-0	0-1-0	0-0-0	0-0-0	0-2-0	2L
Titans	0	2	0	0.000	31	53	-22	0-1-0	0-1-0	0-0-0	0-1-0	0-2-0	2L

AFC West	W	L	T	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Chargers	2	0	0	1.000	47	30	17	1-0-0	1-0-0	2-0-0	2-0-0	2-0-0	2W
Raiders	1	1	0	0.500	29	33	-4	0-1-0	1-0-0	0-1-0	1-1-0	1-1-0	1L
Broncos	1	1	0	0.500	48	41	7	1-0-0	0-1-0	0-0-0	1-1-0	1-1-0	1L
Chiefs	0	2	0	0.000	38	47	-9	0-1-0	0-1-0	0-1-0	0-1-0	0-2-0	2L

NFC East	W	L	T	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Eagles	2	0	0	1.000	44	37	7	1-0-0	1-0-0	1-0-0	1-0-0	2-0-0	2W
Commanders	1	1	0	0.500	39	33	6	1-0-0	0-1-0	1-0-0	1-1-0	1-1-0	1L
Cowboys	1	1	0	0.500	60	61	-1	1-0-0	0-1-0	1-1-0	1-1-0	1-1-0	1W
Giants	0	2	0	0.000	43	61	-18	0-0-0	0-2-0	0-2-0	0-2-0	0-2-0	2L

NFC North	W	L	T	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Packers	2	0	0	1.000	54	31	23	2-0-0	0-0-0	1-0-0	2-0-0	2-0-0	2W
Vikings	1	1	0	0.500	33	46	-13	0-1-0	1-0-0	1-0-0	1-1-0	1-1-0	1L
Lions	1	1	0	0.500	65	48	17	1-0-0	0-1-0	1-1-0	1-1-0	1-1-0	1W
Bears	0	2	0	0.000	45	79	-34	0-1-0	0-1-0	0-2-0	0-2-0	0-2-0	2L

NFC South	W	L	T	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Buccaneers	2	0	0	1.000	43	39	4	0-0-0	2-0-0	1-0-0	1-0-0	2-0-0	2W
Falcons	1	1	0	0.500	42	29	13	0-1-0	1-0-0	0-1-0	1-1-0	1-1-0	1W
Saints	0	2	0	0.000	34	46	-12	0-2-0	0-0-0	0-0-0	0-2-0	0-2-0	2L
Panthers	0	2	0	0.000	32	53	-21	0-0-0	0-2-0	0-0-0	0-1-0	0-2-0	2L

NFC West	W	L	T	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
49ers	2	0	0	1.000	43	34	9	0-0-0	2-0-0	1-0-0	2-0-0	2-0-0	2W
Cardinals	2	0	0	1.000	47	35	12	1-0-0	1-0-0	0-0-0	2-0-0	2-0-0	2W
Rams	2	0	0	1.000	47	28	19	1-0-0	1-0-0	0-0-0	0-0-0	2-0-0	2W
Seahawks	1	1	0	0.500	44	34	10	0-1-0	1-0-0	0-1-0	0-1-0	1-1-0	1W

AFC Conference	W	L	T	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Colts	2	0	0	1.000	62	36	26	2-0-0	0-0-0	0-0-0	2-0-0	2-0-0	2W
Bills	2	0	0	1.000	71	50	21	1-0-0	1-0-0	1-0-0	2-0-0	2-0-0	2W
Chargers	2	0	0	1.000	47	30	17	1-0-0	1-0-0	2-0-0	2-0-0	2-0-0	2W
Bengals	2	0	0	1.000	48	43	5	1-0-0	1-0-0	1-0-0	2-0-0	2-0-0	2W
Raiders	1	1	0	0.500	29	33	-4	0-1-0	1-0-0	0-1-0	1-1-0	1-1-0	1L
Ravens	1	1	0	0.500	81	58	23	1-0-0	0-1-0	1-0-0	1-1-0	1-1-0	1W
Patriots	1	1	0	0.500	46	47	-1	0-1-0	1-0-0	1-0-0	1-1-0	1-1-0	1W
Steelers	1	1	0	0.500	51	63	-12	0-1-0	1-0-0	0-0-0	1-0-0	1-1-0	1L
Broncos	1	1	0	0.500	48	41	7	1-0-0	0-1-0	0-0-0	1-1-0	1-1-0	1L
Jaguars	1	1	0	0.500	53	41	12	1-0-0	0-1-0	0-0-0	0-1-0	1-1-0	1L
Titans	0	2	0	0.000	31	53	-22	0-1-0	0-1-0	0-0-0	0-1-0	0-2-0	2L
Dolphins	0	2	0	0.000	35	66	-31	0-1-0	0-1-0	0-1-0	0-2-0	0-2-0	2L
Chiefs	0	2	0	0.000	38	47	-9	0-1-0	0-1-0	0-1-0	0-1-0	0-2-0	2L
Jets	0	2	0	0.000	42	64	-22	0-2-0	0-0-0	0-1-0	0-2-0	0-2-0	2L
Browns	0	2	0	0.000	33	58	-25	0-1-0	0-1-0	0-2-0	0-2-0	0-2-0	2L
Texans	0	2	0	0.000	28	34	-6	0-1-0	0-1-0	0-0-0	0-0-0	0-2-0	2L

NFC Conference	W	L	T	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Packers	2	0	0	1.000	54	31	23	2-0-0	0-0-0	1-0-0	2-0-0	2-0-0	2W
Eagles	2	0	0	1.000	44	37	7	1-0-0	1-0-0	1-0-0	1-0-0	2-0-0	2W
Buccaneers	2	0	0	1.000	43	39	4	0-0-0	2-0-0	1-0-0	1-0-0	2-0-0	2W
49ers	2	0	0	1.000	43	34	9	0-0-0	2-0-0	1-0-0	2-0-0	2-0-0	2W
Cardinals	2	0	0	1.000	47	35	12	1-0-0	1-0-0	0-0-0	2-0-0	2-0-0	2W
Rams	2	0	0	1.000	47	28	19	1-0-0	1-0-0	0-0-0	0-0-0	2-0-0	2W
Falcons	1	1	0	0.500	42	29	13	0-1-0	1-0-0	0-1-0	1-1-0	1-1-0	1W
Commanders	1	1	0	0.500	39	33	6	1-0-0	0-1-0	1-0-0	1-1-0	1-1-0	1L
Vikings	1	1	0	0.500	33	46	-13	0-1-0	1-0-0	1-0-0	1-1-0	1-1-0	1L
Cowboys	1	1	0	0.500	60	61	-1	1-0-0	0-1-0	1-1-0	1-1-0	1-1-0	1W
Lions	1	1	0	0.500	65	48	17	1-0-0	0-1-0	1-1-0	1-1-0	1-1-0	1W
Seahawks	1	1	0	0.500	44	34	10	0-1-0	1-0-0	0-1-0	0-1-0	1-1-0	1W
Panthers	0	2	0	0.000	32	53	-21	0-0-0	0-2-0	0-0-0	0-1-0	0-2-0	2L
Bears	0	2	0	0.000	45	79	-34	0-1-0	0-1-0	0-2-0	0-2-0	0-2-0	2L
Saints	0	2	0	0.000	34	46	-12	0-2-0	0-0-0	0-0-0	0-2-0	0-2-0	2L
Giants	0	2	0	0.000	43	61	-18	0-0-0	0-2-0	0-2-0	0-2-0	0-2-0	2L

NFL Team	W	L	T	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Cardinals	2	0	0	1.000	47	35	12	1-0-0	1-0-0	0-0-0	2-0-0	2-0-0	2W
Bills	2	0	0	1.000	71	50	21	1-0-0	1-0-0	1-0-0	2-0-0	2-0-0	2W
Bengals	2	0	0	1.000	48	43	5	1-0-0	1-0-0	1-0-0	2-0-0	2-0-0	2W
Packers	2	0	0	1.000	54	31	23	2-0-0	0-0-0	1-0-0	2-0-0	2-0-0	2W
Colts	2	0	0	1.000	62	36	26	2-0-0	0-0-0	0-0-0	2-0-0	2-0-0	2W
Chargers	2	0	0	1.000	47	30	17	1-0-0	1-0-0	2-0-0	2-0-0	2-0-0	2W
Rams	2	0	0	1.000	47	28	19	1-0-0	1-0-0	0-0-0	0-0-0	2-0-0	2W
Eagles	2	0	0	1.000	44	37	7	1-0-0	1-0-0	1-0-0	1-0-0	2-0-0	2W
49ers	2	0	0	1.000	43	34	9	0-0-0	2-0-0	1-0-0	2-0-0	2-0-0	2W
Buccaneers	2	0	0	1.000	43	39	4	0-0-0	2-0-0	1-0-0	1-0-0	2-0-0	2W
Falcons	1	1	0	0.500	42	29	13	0-1-0	1-0-0	0-1-0	1-1-0	1-1-0	1W
Ravens	1	1	0	0.500	81	58	23	1-0-0	0-1-0	1-0-0	1-1-0	1-1-0	1W
Cowboys	1	1	0	0.500	60	61	-1	1-0-0	0-1-0	1-1-0	1-1-0	1-1-0	1W
Broncos	1	1	0	0.500	48	41	7	1-0-0	0-1-0	0-0-0	1-1-0	1-1-0	1L
Lions	1	1	0	0.500	65	48	17	1-0-0	0-1-0	1-1-0	1-1-0	1-1-0	1W
Jaguars	1	1	0	0.500	53	41	12	1-0-0	0-1-0	0-0-0	0-1-0	1-1-0	1L
Raiders	1	1	0	0.500	29	33	-4	0-1-0	1-0-0	0-1-0	1-1-0	1-1-0	1L
Vikings	1	1	0	0.500	33	46	-13	0-1-0	1-0-0	1-0-0	1-1-0	1-1-0	1L
Patriots	1	1	0	0.500	46	47	-1	0-1-0	1-0-0	1-0-0	1-1-0	1-1-0	1W
Steelers	1	1	0	0.500	51	63	-12	0-1-0	1-0-0	0-0-0	1-0-0	1-1-0	1L
Seahawks	1	1	0	0.500	44	34	10	0-1-0	1-0-0	0-1-0	0-1-0	1-1-0	1W
Commanders	1	1	0	0.500	39	33	6	1-0-0	0-1-0	1-0-0	1-1-0	1-1-0	1L
Panthers	0	2	0	0.000	32	53	-21	0-0-0	0-2-0	0-0-0	0-1-0	0-2-0	2L
Bears	0	2	0	0.000	45	79	-34	0-1-0	0-1-0	0-2-0	0-2-0	0-2-0	2L
Browns	0	2	0	0.000	33	58	-25	0-1-0	0-1-0	0-2-0	0-2-0	0-2-0	2L
Texans	0	2	0	0.000	28	34	-6	0-1-0	0-1-0	0-0-0	0-0-0	0-2-0	2L
Chiefs	0	2	0	0.000	38	47	-9	0-1-0	0-1-0	0-1-0	0-1-0	0-2-0	2L
Dolphins	0	2	0	0.000	35	66	-31	0-1-0	0-1-0	0-1-0	0-2-0	0-2-0	2L
Saints	0	2	0	0.000	34	46	-12	0-2-0	0-0-0	0-0-0	0-2-0	0-2-0	2L
Giants	0	2	0	0.000	43	61	-18	0-0-0	0-2-0	0-2-0	0-2-0	0-2-0	2L
Jets	0	2	0	0.000	42	64	-22	0-2-0	0-0-0	0-1-0	0-2-0	0-2-0	2L
Titans	0	2	0	0.000	31	53	-22	0-1-0	0-1-0	0-0-0	0-1-0	0-2-0	2L