NFL Betting Preview: Seahawks vs Cardinals

The Seattle Seahawks clash with the Arizona Cardinals in this NFL Week 4 Thursday Night Football matchup at State Farm Stadium, with kickoff scheduled for 08:15 on Friday 26 September. Our betting preview features expert predictions, picks, updated betting odds, head-to-head stats and the latest team news, including injuries.

Why Seahawks Can Claim the Win

We think that the Seahawks should prove too strong for the Cardinals. Therefore, it’s all about going to the Moneyline to back them and there’s juice in the 1.86 available.

Going with Seahawks for the W? Take your wager further by claiming the current Stake promo code and reading our comprehensive site review.

8 of Last 10 H2H Matchups Have Been Seahawks Wins

Seattle Seahawks claimed a home victory in their previous game. A 44-13 triumph against New Orleans Saints at Lumen Field made it back-to-back wins. The Seahawks put up 320 yards, split between 233 passing and 87 rushing yards. The offense moved the chains 22 times and struck for 5 touchdowns.

Arizona Cardinals suffered a defeat in their last game. A 16-15 scoreline occurred on the road at Levi's Stadium against San Francisco 49ers. The Cardinals totaled 260 yards, split between 154 passing and 106 rushing yards. They moved the chains 16 times and found the end zone once through the air.

Head-to-Head Statistics

The Seahawks beat the Cardinals when the teams last met. It was a 30-18 scoreline at State Farm Stadium. The previous 10 games featuring these teams have resulted in eight Seahawks victories.

Quarterbacks

Sam Darnold

Kyler Murray

Seahawks vs Cardinals Prediction & Picks

Take in the full Seahawks vs Cardinals betting outlook — from our expert match prediction and correct score pick to player prop insights and a bet builder tailored for value.

Game Prediction

There are lots of reasons to support the pick that the Seahawks will win this NFL showdown. Therefore, we’re heading to the Moneyline where you can get 1.86.

To deliver the best possible NFL predictions, we start by locking in the team news and taking time to review the latest form. There’s also no shortage of data to crunch from the most up-to-date stats available.

Key Seahawks vs Cardinals stats:

Seahawks have won 7 consecutive games on the road.
Seahawks have won 9 of their last 10 games on the road.
Seahawks have won 12 of their last 20 games.
Cardinals have lost 6 of their last 10 games.
Cardinals have lost 11 of their last 20 games at home.
Cardinals have lost their last 7 games against Seahawks.

Seahawks Moneyline Probability

If you go by the top betting sites, there’s a 53.8% likelihood of our pick landing a return. Based on our analysts research, we calculate the actual probability to be closer to 60%. The wager can be recommended for this precise reason.

Looking for Bigger Odds?

If you’re looking for bigger odds, then the Seahawks on the Double Result lines could be a good way forward. You need them to lead at the halfway stage and then claim a victory.

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Best Bet

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Gamble responsibly 18+. All odds are correct at time of publishing and are subject to change. To use the Bookmaker Live Streaming services you will need to be logged in and have a funded account or to have placed a bet in the last 24 hours. Geo-restrictions apply.

Published 14:26, 24 September 2025

Player Prop Picks

Top Pick: Kyler Murray Under 209.5 Passing Yards

The odds for Kyler Murray (Cardinals) to record fewer than 209.5 passing yards are 1.88. He may fall short of the QB Passing Yards line, making this prop bet a strong pick.

Latest Kyler Murray Player Prop Odds

Touchdown

Passing Yards

Rushing Yards

Sam Darnold Under 7.5 Rushing Yards

You can place a bet on Sam Darnold (Cardinals) at 1.82 to record fewer than 7.5 rushing yards. There’s no reason to doubt our instinct, so we’ll bet on him falling short of the Player Rushing Yards line.

Latest Sam Darnold Player Prop Odds

Touchdown

Passing Yards

Rushing Yards

Same Game Parlay Picks

Moneyline Seahawks

Totals Over 43.5

Passing Yards Kyler Murray Under 209.5

Get in the game with this same game parlay. Our selections are Seahawks on the moneyline, Over 43.5 on the total and Kyler Murray (Cardinals) to go Under 209.5 passing yards.

A same game parlay is a great alternative for football bettors who want to focus their wagering on a single event. You can predict different outcomes and see their odds combined before going ahead and placing this tailored bet.

T&C apply. Gamble responsibly 18+

Correct Score Prediction

Seahawks

27 - 24 Cardinals logo

Cardinals

We’re expecting this to be a close battle and we’ll take the Seahawks to win 27-24. This is available at huge odds for those that want to have a speculative wager.

Seahawks vs Cardinals Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Close Game On the Cards According to Latest Odds

You can back Arizona Cardinals at 2.08 to win against Seattle Seahawks, with the latter trading at 1.79. If you want to know the probability of the road team winning this game, it’s 56% according to the most popular sportsbooks.

The spread is currently 1.5, with the total points line at 43.5. NFL bettors love the chance to get an alternative angle by going for a Total wager. If you’re going for Under 43.5, this outcome can be backed at 1.87.

Take a well-rounded approach when placing your bets. The top NFL betting sites are packed with team props and game lines, so focus on finding the selection that reflects your read on the matchup.

Moneyline

Point Spread

Total Points

Kenneth Walker III Favorite to Be First TD Scorer

Kenneth Walker III can be backed to score a TD at any stage at 2.08. There is the opportunity to back the market leader to grab the first touchdown at 6.50.

Touchdown

Kenneth Walker III (Seahawks)

Trey Benson (Cardinals)

Trey McBride (Cardinals)

Jaxon Smith-Njigba (Seahawks)

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Receiving Yards

Jaxon Smith-Njigba (Seahawks)

Trey McBride (Cardinals)

Marvin Harrison Jr. (Cardinals)

Cooper Kupp (Seahawks)

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Rushing Yards

Trey Benson (Cardinals)

Kenneth Walker III (Seahawks)

Zach Charbonnet (Seahawks)

Kyler Murray (Cardinals)

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Passing Yards

Sam Darnold (Seahawks)

Kyler Murray (Cardinals)

Micro Betting

For those looking to enjoy a thrilling in-game wager, then NFL micro betting could be up your street. You are now able to wager on what will happen on the next snap by staking your money on the Next Play Result.

Best Betting Offers

State Farm Stadium

Seahawks Have Bossed Recent Head-to-Heads at State Farm Stadium

The Cardinals have run off three straight victories at State Farm Stadium. They have seven wins and three losses in the last 10 home games, putting up 26.70 points per contest and giving up 19.50.

The Seahawks have reeled off seven straight road wins. They have nine wins and one loss in the last 10 road games, averaging 25.00 points on offense and surrendering 19.70 on defense.

The last time the Seahawks faced the Cardinals at State Farm Stadium, they won 30-18. Over the previous 6 head-to-head clashes at State Farm Stadium, the Seahawks have collected five victories, while the Cardinals have one.

Last 10 Games		W-L	P	PF	PA	O43.5	U43.5
Cardinals Home Stats		7-3	46.20	26.70	19.50	6	4
Seahawks Away Stats		9-1	44.70	25.00	19.70	6	4

W-L = Wins-Losses
P = Avg. Points
PF = Avg. Points For
PA = Avg. Points Against
O43.5 = Games Over 43.5 Points
U43.5 = Games Under 43.5 Points

Last 5 & H2H

All
Home
Away

Last 5 Games

Seahawks

NFL: 21/09 Saints13 Seahawks 44
NFL: 14/09 Seahawks31 Steelers 17
NFL: 07/09 49ers17 Seahawks 13
NFL: 05/01 Seahawks30 Rams 25
NFL: 27/12 Seahawks6 Bears 3

Cardinals

NFL: 21/09 Cardinals15 49ers 16
NFL: 14/09 Panthers22 Cardinals 27
NFL: 07/09 Cardinals20 Saints 13
NFL: 05/01 49ers24 Cardinals 47
NFL: 29/12 Cardinals9 Rams 13

Head to Head

Seahawks vs Cardinals

NFL: 08/12 2024 Seahawks 30 Cardinals 18
NFL: 24/11 2024 Cardinals 6 Seahawks 16
NFL: 07/01 2024 Seahawks 21 Cardinals 20
NFL: 22/10 2023 Cardinals 10 Seahawks 20
NFL: 06/11 2022 Seahawks 31 Cardinals 21
NFL: 16/10 2022 Cardinals 9 Seahawks 19
NFL: 09/01 2022 Seahawks 38 Cardinals 30
NFL: 21/11 2021 Cardinals 23 Seahawks 13
NFL: 20/11 2020 Cardinals 21 Seahawks 28
NFL: 26/10 2020 Seahawks 34 Cardinals 37

Team Stats

Latest regular season and playoff games stats.

Seattle Seahawks Stats

Arizona Cardinals Stats

Moneyline

7 wins and 3 defeats in the last 10 games
9 wins and 1 defeat in the last 10 games on the road

Moneyline

4 wins and 6 defeats in the last 10 games
7 wins and 3 defeats in the last 10 home games

Point Spread

-1.5 Betting Line: Have covered the spread in 7 of the last 10 games
-1.5 Betting Line on the Road: Have covered the spread in 8 of the last 10 games on the road

Point Spread

+1.5 Betting Line: Have covered the spread in 6 of the last 10 games
+1.5 Betting Line at Home: Have covered the spread in 7 of the last 10 home games

Total Points

Game Totals: An average of 41.00 pts in the previous 10 games
Game Totals on the Road: An average of 44.70 pts in the previous 10 games on the road
Over 43.5: Covered in 6 of the previous 10 games
Over 43.5 on the Road: Covered in 6 of the previous 10 games on the road
Team Totals: Have scored an average of 23.30 pts and allowed 17.70 pts in the last 10 games
Team Totals on the Road: Have scored an average of 25.00 pts and allowed 19.70 pts in the last 10 games on the road

Total Points

Game Totals: An average of 43.40 pts in the previous 10 games
Game Totals at Home: An average of 46.20 pts in the previous 10 home games
Over 43.5: Covered in 6 of the previous 10 games
Over 43.5 at Home: Covered in 6 of the previous 10 home games
Team Totals: Have scored an average of 22.40 pts and allowed 21.00 pts in the last 10 games
Team Totals at Home: Have scored an average of 26.70 pts and allowed 19.50 pts in the last 10 home games

Game Stats

Last 10 Games

Total Yards: Gained 306.50 Yds. Allowed 309.60 Yds
Rushing Yards: Gained 100.00 Yds. Allowed 93.70 Yds
Passing Yards: Gained 206.50 Yds. Allowed 215.90 Yds
Total Touchdowns: Scored 2.60 TD. Allowed 1.70 TD
Rushing Touchdowns: Scored 0.80 TD. Allowed 0.10 TD
Passing Touchdowns: Scored 1.50 TD. Allowed 1.50 TD
Total 1st Downs: Picked up 17.50. Allowed 18.20
Total Turnovers: Committed 1.30. Committed by opponents 1.30
Total Penalties: Committed 5.50. Committed by opponents 6.30
Penalty Yards: Lost 50.60 Yds. Gained 47.50 Yds

Game Stats

Last 10 Games

Total Yards: Gained 345.20 Yds. Allowed 333.30 Yds
Rushing Yards: Gained 127.40 Yds. Allowed 104.70 Yds
Passing Yards: Gained 217.80 Yds. Allowed 228.60 Yds
Total Touchdowns: Scored 2.20 TD. Allowed 2.30 TD
Rushing Touchdowns: Scored 0.70 TD. Allowed 0.90 TD
Passing Touchdowns: Scored 1.30 TD. Allowed 1.40 TD
Total 1st Downs: Picked up 20.50. Allowed 19.50
Total Turnovers: Committed 1.00. Committed by opponents 0.90
Total Penalties: Committed 7.00. Committed by opponents 7.50
Penalty Yards: Lost 56.00 Yds. Gained 65.00 Yds

Last 10 Games on the Road

Total Yards: Gained 349.30 Yds. Allowed 329.00 Yds
Rushing Yards: Gained 113.90 Yds. Allowed 126.20 Yds
Passing Yards: Gained 235.40 Yds. Allowed 202.80 Yds
Total Touchdowns: Scored 2.80 TD. Allowed 2.20 TD
Rushing Touchdowns: Scored 1.10 TD. Allowed 0.70 TD
Passing Touchdowns: Scored 1.40 TD. Allowed 1.40 TD
Total 1st Downs: Picked up 19.80. Allowed 18.90
Total Turnovers: Committed 0.80. Committed by opponents 1.30
Total Penalties: Committed 4.60. Committed by opponents 6.30
Penalty Yards: Lost 35.20 Yds. Gained 47.60 Yds

Last 10 Home Games

Total Yards: Gained 357.90 Yds. Allowed 341.80 Yds
Rushing Yards: Gained 154.70 Yds. Allowed 114.30 Yds
Passing Yards: Gained 203.20 Yds. Allowed 227.50 Yds
Total Touchdowns: Scored 3.20 TD. Allowed 2.00 TD
Rushing Touchdowns: Scored 1.40 TD. Allowed 1.00 TD
Passing Touchdowns: Scored 1.40 TD. Allowed 1.00 TD
Total 1st Downs: Picked up 21.00. Allowed 20.60
Total Turnovers: Committed 0.90. Committed by opponents 1.20
Total Penalties: Committed 4.60. Committed by opponents 6.30
Penalty Yards: Lost 43.70 Yds. Gained 52.80 Yds

Team News

Seattle Seahawks Injuries

Type

Name

Info

Anthony Bradford

Back

Zach Charbonnet

Foot

Nick Emmanwori

Ankle

AJ Finley

Knee

Johnathan Hankins

Back

Christian Haynes

Pectoral

Josh Jones

Ankle

Boye Mafe

Toe

Kenny McIntosh

Knee - ACL

Rylie Mills

Knee - ACL

Robbie Ouzts

Ankle

Arizona Cardinals Injuries

Type

Name

Info

Kelvin Beachum

Knee

Joey Blount

Neck

Evan Brown

Ankle

L.J. Collier

Knee

Hayden Conner

Knee

James Conner

Foot

Akeem Davis-Gaither

Elbow

Darren Hall

Ankle

Will Hernandez

Knee - ACL

Paris Johnson

Knee

Will Johnson

Groin

Christian Jones

Knee

Justin Jones

Knee

Zay Jones

Concussion

Sean Murphy-Bunting

Knee

Bilal Nichols

Neck

Walter Nolen

Calf

BJ Ojulari

Knee - ACL

J.J. Russell

Concussion

Valentin Senn

Undisclosed

Starling Thomas

Knee - ACL

Garrett Williams

Knee

Previous Seattle Seahawks Lineups

22 Sep NFL

Saints 13-44 Seahawks

AFC East	W	L	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Bills	3	0	1.000	102	71	31	2-0-0	1-0-0	2-0-0	3-0-0	3-0-0	3W
Patriots	1	2	0.333	60	68	-8	0-2-0	1-0-0	1-0-0	1-2-0	1-2-0	1L
Jets	0	3	0.000	69	93	-24	0-2-0	0-1-0	0-1-0	0-2-0	0-3-0	3L
Dolphins	0	3	0.000	56	97	-41	0-1-0	0-2-0	0-2-0	0-3-0	0-3-0	3L

AFC North	W	L	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Bengals	2	1	0.667	58	91	-33	1-0-0	1-1-0	1-0-0	2-0-0	2-1-0	1L
Steelers	2	1	0.667	72	77	-5	0-1-0	2-0-0	0-0-0	2-0-0	2-1-0	1W
Ravens	1	2	0.333	111	96	15	1-1-0	0-1-0	1-0-0	1-1-0	1-2-0	1L
Browns	1	2	0.333	46	68	-22	1-1-0	0-1-0	0-2-0	0-2-0	1-2-0	1W

AFC South	W	L	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Colts	3	0	1.000	103	56	47	2-0-0	1-0-0	1-0-0	3-0-0	3-0-0	3W
Jaguars	2	1	0.667	70	51	19	2-0-0	0-1-0	1-0-0	1-1-0	2-1-0	1W
Texans	0	3	0.000	38	51	-13	0-1-0	0-2-0	0-1-0	0-1-0	0-3-0	3L
Titans	0	3	0.000	51	94	-43	0-2-0	0-1-0	0-1-0	0-2-0	0-3-0	3L

AFC West	W	L	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Chargers	3	0	1.000	70	50	20	2-0-0	1-0-0	3-0-0	3-0-0	3-0-0	3W
Raiders	1	2	0.333	53	74	-21	0-1-0	1-1-0	0-1-0	1-1-0	1-2-0	2L
Broncos	1	2	0.333	68	64	4	1-0-0	0-2-0	0-1-0	1-2-0	1-2-0	2L
Chiefs	1	2	0.333	60	56	4	0-1-0	1-1-0	0-1-0	0-1-0	1-2-0	1W

NFC East	W	L	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Eagles	3	0	1.000	77	63	14	2-0-0	1-0-0	1-0-0	2-0-0	3-0-0	3W
Commanders	2	1	0.667	80	57	23	2-0-0	0-1-0	1-0-0	1-1-0	2-1-0	1W
Cowboys	1	2	0.333	74	92	-18	1-0-0	0-2-0	1-1-0	1-2-0	1-2-0	1L
Giants	0	3	0.000	52	83	-31	0-1-0	0-2-0	0-2-0	0-2-0	0-3-0	3L

NFC North	W	L	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Packers	2	1	0.667	64	44	20	2-0-0	0-1-0	1-0-0	2-0-0	2-1-0	1L
Vikings	2	1	0.667	81	56	25	1-1-0	1-0-0	1-0-0	1-1-0	2-1-0	1W
Lions	2	1	0.667	103	78	25	1-0-0	1-1-0	1-1-0	1-1-0	2-1-0	2W
Bears	1	2	0.333	76	93	-17	1-1-0	0-1-0	0-2-0	1-2-0	1-2-0	1W

NFC South	W	L	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
Buccaneers	3	0	1.000	72	66	6	1-0-0	2-0-0	1-0-0	1-0-0	3-0-0	3W
Panthers	1	2	0.333	62	53	9	1-0-0	0-2-0	1-0-0	1-1-0	1-2-0	1W
Falcons	1	2	0.333	42	59	-17	0-1-0	1-1-0	0-2-0	1-2-0	1-2-0	1L
Saints	0	3	0.000	47	90	-43	0-2-0	0-1-0	0-0-0	0-3-0	0-3-0	3L

NFC West	W	L	PCT	PF	PA	N. Pts	Home	Road	Div	Conf	Last 5	Strk
49ers	3	0	1.000	59	49	10	1-0-0	2-0-0	2-0-0	3-0-0	3-0-0	3W
Cardinals	2	1	0.667	62	51	11	1-0-0	1-1-0	0-1-0	2-1-0	2-1-0	1L
Seahawks	2	1	0.667	88	47	41	1-1-0	1-0-0	0-1-0	1-1-0	2-1-0	2W
Rams	2	1	0.667	73	61	12	1-0-0	1-1-0	0-0-0	0-1-0	2-1-0	1L

NFL Betting Preview: Seahawks vs Cardinals

Head-to-Head Statistics

Seahawks vs Cardinals Prediction & Picks

Game Prediction

Seahawks Moneyline Probability

Best Bet

Player Prop Picks

Same Game Parlay Picks

Correct Score Prediction

Seahawks vs Cardinals Odds

Last 5 & H2H

Team News

Seattle Seahawks Injuries

Arizona Cardinals Injuries

Previous Seattle Seahawks Lineups

Previous Arizona Cardinals Lineups

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